Berberine –  Berberine Hydrochloride (HCL),  Berberine Sulphate & Berberine Tannate manufactured as nutraceutical ingredient and health supplement

Berberine is an API that is used by the Pharmaceutical, Drug, and Natural Products industry.


CAS Number: 633-66-9

Molecular formula: C20H18NO4+

Berberine is a quaternary ammonium salt from the group of isoquinoline alkaloids. It is strongly yellow coloured, which is why in earlier times berberis species were used to dye wool, leather and wood. Wool is still today dyed with berberine in Northern India. Under ultraviolet light, it shows a strong yellow fluorescence because of this it is used in histology for staining heparin in mast cells.  As a natural dye Berberine has a Colour Index (CI) of 75160. It has also used medically in Diabetes, dyslipidemias, cardiovascular conditions, cancer and mental health.

HimPharm manufactures three varieties of Berberine, namely

  • Berberine Hydrochloride, Berberine Chloride or Berberine HCL,
  • Berberine Sulphate or Sulfate, 
  • and Berberine Tannate.

There is strong clinical data with human studies to suggest that Berberine is highly effective in helping reduce blood sugar level in diabetic patients. Its usage has been compared with oral hypoglycemic drugs like Metformin, Rosiglitazone or Glibenclamide; which suggests berberine is one of the more effective supplements for blood glucose reductions. Berberine supplements are used for their anti-inflammatory and anti-diabetic effects. It may improve intestinal health & help in lowering cholesterol. Berberine is documented to be able to reduce glucose production in the liver. The reduction of HbA1c associated with it seems in trials to be more significant reductions associated with dietary supplements. Total cholesterol notably decreased.

Berberine for reducing blood glucose – The usage of berberine in reducing blood glucose is akin to drugs like Metformin or Glibenclamide; this suggests berberine is one of the most effective natural supplements for blood glucose reductions. Very strong human trials have been conducted on the effect of Berberine on blood sugar levels, In a human trial Berberine along with lifestyle alterations improved liver fat content, BMI, total cholesterol &  triglycerides significantly more than lifestyle changes alone. In another study Berberine in isolation at 1g for 3 months helped reduce triglycerides & fasting glucose levels in type II diabetics. Total cholesterol and LDL also decreased, and an increase in glucose disposal rate was observed. Insulin sensitivity also showed improvement. In another study on over 1000 diabetic subjects, Berberine supplementation between 500 to 1500 mg taken daily for 12 weeks led to minor & moderate improvements on all measured glucose & lipid parameters. In diabetics, there was observed a reduction of HbA1c with berberine. This reduction is a significant reduction because of dietary supplementation.

Berberine for cholesterol – Total cholesterol appears to decrease with Berberine supplements. A minor improvement in HDL-C, the good cholesterol was also noted in trials. The reduction of LDL-C & triglycerides when berberine was joined with lifestyle changes suggested a significant benefit but was not adjudged as remarkably potent. However, this research is not conclusive and additional human trials would be needed to confirm this action of berberine.

Berberine’s other uses – Berberine may also work with anti-depressants and help with fat loss, however, these benefits need additional evidence and trials before berberine may be used specifically for these conditions.

How to take – The standard dose of Berberine varies between 900 milligrams to 2000 mg in a day, divided into three to four doses. Berberine, when taken in high doses, may cause cramping & diarrhoea. This is the reason that we suggest berberine be taken in multiple doses through the day. It should be taken with a meal, or shortly after consuming a meal so as to take advantage of the blood glucose & the resulting lipid spike associated with eating food.

Berberine can interact with enzymes of drug metabolism., macrolide antibiotics (azithromycin & clarithromycin) which could result in serious cardiotoxicity. Please consult with your physician before starting Berberine supplementation or if you are using the above-indicated drugs.

HimPharm manufactures Berberine compounds, including Berberine Hydrochloride (also called Berberine HCL or Berberine Chloride), Berberine Sulphate, and Berberine Tannate in bulk quantities. These are manufactured for further use or formulation in natural products, health supplements or dietary supplements.

Get in touch with us, through our contact us page to know more about the qualities of Berberine compounds we manufacture, enquire about the price, packaging or source a COA or MSDS for Berberine HCL, Berberine Sulfate or Berberine Tannate.

We regularly export berberine compounds to many destinations all over the world, through Air or Sea freight – get in touch with HimPharm to provide a detailed quote with insurance and freight for your nearest airport or seaport.