Category: Phytochemical
Trade Names: Colcrys, Mitigare
Routes of Administration: Oral, Intravenous
ATC Code: M04AC01
Identifiers
Chemical and Physical Data
SMILES: COC1=C(C=C2C(=C1)C(=O)C3= CC=CC=C3N2)OCOC4=CC=C(C=C4)OC(=O)C
InChI: InChI=1S/C22H25NO6/c1-26-16-8-6-13(7-9-16)4-5-21-15-10-19(28-3)17(27-2)12-18(15)29-20(21)11-14-22(23)24/h6-12H,4-5H2,1-3H3
Colchicine, a natural marvel with a fascinating history and diverse applications in the pharmaceutical, drug, and natural products industry.
Colchicine is a toxic natural product and secondary metabolite, finds its roots in the plants of the genus Colchicum, specifically the Autumn crocus (Colchicum autumnale) or Meadow saffron. Initially utilized for treating rheumatic complaints, especially gout, Colchicine has stood the test of time and continues to be relevant today.
Its uniqueness lies in its dual role as a therapeutic agent and a subject of ongoing anti-cancer drug investigations. Colchicine’s impact extends beyond its medicinal use for gout and familial Mediterranean fever. It serves as an initial treatment for pericarditis and is under investigation for its potential as an anti-cancer drug.
At its core, Colchicine is a chemical compound which is extracted from plants. It has evolved from a traditional remedy for rheumatic ailments to a key player in modern medicine.
Colchicine’s applications go beyond conventional medicine. It is a versatile compound with diverse therapeutic purposes, making it a valuable asset in pharmaceuticals, health, and the drug industry.
Colchicine exhibits distinct physical characteristics that contribute to its identification and application.
Colchicine typically presents itself as a pale yellow to yellowish-white crystalline powder. This characteristic hue is a defining visual aspect, aiding in the recognition of the compound.
In its pure form, Colchicine is virtually odorless. This lack of a strong or distinct scent is advantageous, especially in pharmaceutical applications where the focus is on the compound’s chemical properties rather than its fragrance.
Similarly, Colchicine is known for its lack of a pronounced taste. Its taste is often described as bitter, but the bitterness is relatively mild. This characteristic allows for easier incorporation into medicinal formulations without significantly affecting the taste profile.
Colchicine is sparingly soluble in water, which means it dissolves to a limited extent. This solubility profile influences its pharmacokinetics and the ways in which it can be administered in medicinal formulations.
The compound has a melting point of approximately 150°C to 153°C (302°F to 307°F). This specific temperature range is a critical parameter during the manufacturing process, ensuring the proper handling and transformation of Colchicine.
The crystalline structure of Colchicine contributes to its powder form. The compound’s arrangement in crystals influences its physical properties and can impact its behavior during various stages of production and formulation.
Colchicine’s origin story is a fascinating narrative that intertwines botanical exploration, ancient remedies, and modern scientific inquiry.
Colchicine’s history can be traced back to ancient civilizations, where it was first identified through the medicinal properties of plants belonging to the Colchicum genus. The Autumn crocus (Colchicum autumnale), also known as Meadow saffron, was particularly significant in this context.
Ancient healers, often guided by empirical knowledge, recognized the plant’s effectiveness in treating rheumatic complaints, especially gout.
The process of isolating the active compound within Colchicum plants, eventually identified as Colchicine, began in the 19th century. The breakthrough came with the work of the French chemists P.S. Pelletier and J.B. Caventou in 1820. Their meticulous extraction and analysis efforts marked the beginning of a more scientific understanding of Colchicine.
Colchicine’s therapeutic applications were initially centered around its anti-inflammatory properties, making it a sought-after remedy for gout. Its cathartic and emetic effects were also noted, adding to its medicinal versatility. The compound gained popularity in the treatment of rheumatic complaints, becoming a staple in traditional medicine.
The early methods of Colchicine extraction involved laborious processes, often reliant on the natural abundance of Colchicum plants. However, as scientific understanding advanced, the need for a more sustainable and controlled manufacturing process became apparent.
Colchicine, with its versatile properties, finds diverse applications in the pharmaceutical, health, and drug industry.
Beyond Therapy: Additional Properties and Applications
In the world of APIs and Colchicine bulk manufacturing, HimPharm stands as a stalwart. With a legacy dating back to 1979, HimPharm has been a pioneer in the manufacturing business of Active Pharmaceutical Ingredients (APIs). The company’s deep experience in the herbs and herbal products trade, spanning over a century, adds a layer of expertise to its role in Colchicine production.
Quality assurance is the cornerstone of HimPharm’s manufacturing process. The company’s commitment to maintaining international standards ensures that the Colchicine produced meets stringent quality benchmarks. HimPharm’s modern facility is equipped with cutting-edge technology and a robust quality assurance team, guaranteeing products of exceptional quality.
Whether your business demands small batches or large quantities of Colchicine, HimPharm is poised to meet your needs. The company’s flexibility in offering smaller lots and scaling manufacturing from small to large batches underscores its commitment to addressing the diverse requirements of clients.
HimPharm’s long-standing presence in the industry equips it with a unique advantage in overcoming challenges. Through strategies and innovations employed, enable HimPharm to navigate hurdles, ensuring a seamless and efficient Colchicine manufacturing process.
HimPharm’s commitment to innovation and efficiency enables the company to navigate potential production bottlenecks effectively. Continuous improvement initiatives and investment in research and development contribute to the optimization of Berberine production processes.
Conclusion on Colchicine and HimPharm’s role in its production, let’s recap the key takeaways. From the compound’s historical significance to its modern applications and HimPharm’s commitment to quality, this article has provided a comprehensive understanding of Colchicine and the value proposition offered by HimPharm.
For businesses seeking a reliable source of Colchicine, HimPharm emerges as a partner of choice. The company’s unwavering commitment to quality, backed by a state-of-the-art manufacturing facility, positions it as a leader in the production of premium Colchicine. Explore the possibilities with HimPharm and elevate your sourcing experience.
What sets Colchicine apart from other medicinal compounds?
Colchicine’s uniqueness lies in its dual role as a therapeutic agent and ongoing investigations for anti-cancer properties. Its historical relevance and modern applications make it a standout compound in the pharmaceutical landscape.
How does HimPharm ensure the quality of its Colchicine products?
HimPharm upholds international standards for quality assurance. With a well-equipped modern facility and a dedicated quality assurance team, the company ensures that every batch of Colchicine meets the highest standards.
Can HimPharm accommodate varying quantity requirements for Colchicine orders?
Yes, HimPharm’s flexibility extends to meeting diverse quantity needs. Whether you require small lots or large batches of Colchicine, the company is equipped to cater to your specific requirements.
What alternatives are explored for Colchicine extraction, apart from Colchicum plants?
HimPharm looks for alternative sources, with a specific focus on gloriosa superba. Exploring diverse botanical origins ensures a sustainable and varied supply chain for Colchicine production.
How does HimPharm navigate challenges in Colchicine manufacturing?
With decades of experience, HimPharm employs strategic approaches and innovations to overcome challenges in Colchicine production. The company’s resilience and problem-solving capabilities contribute to a seamless manufacturing process.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
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