Crude Diosgenin
Wild Yam Extract

Written by

Reviewed by

Picture of Gaurav Sood
Gaurav Sood

Partner - HimPharm

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Dr B M Sood

Chairman - HimPharm

Diosgenin & Crude Diosgenin Manufactured by HimPharm

Category: Phytochemical
Trade Names: None (Often sold as Diosgenin, Wild Yam Extract)
Routes of Administration: Oral, Topical
ATC Code: Not Applicable


  • CAS Number: 512-04-9
  • PubChem CID: 446392
  • ChemSpider ID: 393225

Chemical and Physical Data

  • Molecular Formula C27H42O3
    Molar Mass 414.63 g/mol


InChI: InChI=1S/C27H42O3/c1-16-6-10-27(30)16(2)12-17(29)11-14-25-19(7-8-22(28)24(25)21(16)13-18(14)26(27)31-25)20(9-15-5-4-15)23(29)3/h14-21,23-26,28-30H,4-13H2,1-3H3/t14-,15-,16+,17+,18-,19+,20+,21+,23-,24-,25+,26-,27+/m1/s1


What is Diosgenin?

Diosgenin, with the chemical formula C27H42O3 and CAS number 512-04-9, is a natural steroid found in certain plants. It serves as a crucial precursor for the semi-synthesis of progesterone, a hormone that played a pivotal role in early combined oral contraceptive pills.

Diosgenin, in its unmodified form, exhibits estrogenic activity and has the potential to reduce serum cholesterol levels. This compound is not only significant in contraceptive formulations but also serves as a precursor for the synthesis of corticosteroids and sex hormones, including DHA and prednisolone.


Impact of Diosgenin on Pharmaceutical, Drug, and Natural Products Industry

In the world of health, wellness, herbal medicine, and the pharmaceutical sector, Diosgenin is a versatile compound with far-reaching implications. Its influence is profound in the synthesis of various hormones and pharmaceuticals. 

Diosgenin’s estrogenic properties open avenues for applications in hormonal therapies, while its role in cholesterol reduction aligns with the growing emphasis on natural remedies for heart health.

Understanding Diosgenin

What is Diosgenin?

Diosgenin, sometimes referred to as natural steroids, is a naturally occurring steroid obtained from certain plant sources, primarily Dioscorea species. Its molecular structure and reactivity make it a valuable building block for the synthesis of various pharmaceutical compounds. 

Diosgenin’s significance lies in its versatility and pivotal role in the pharmaceutical and healthcare industries.

What is it used in?

Diosgenin’s applications extend across diverse areas within the pharmaceutical and drug manufacturing sectors. Its initial use in combined oral contraceptive pills highlights its importance in reproductive health. 

Additionally, Diosgenin serves as a precursor for corticosteroids and various sex hormones, contributing to the synthesis of essential compounds such as DHA and prednisolone.

What does it look like?

In its isolated form, Diosgenin appears as a crystalline powder with distinct physical properties. The compound’s appearance is a critical factor for pharmaceutical manufacturers, ensuring the purity and quality of the Diosgenin used in their processes.

Where does it come from – how is it obtained or processed?

The primary natural source of Diosgenin is certain species of Dioscorea, commonly known as wild yam or Chinese yam. Diosgenin is extracted from the tubers or roots of these plants through a series of extraction and purification processes. The careful extraction ensures the isolation of Diosgenin in its pure form, ready for pharmaceutical applications.

Why is it considered important?

The importance of Diosgenin, also called wild yam extract stems from its role as a precursor in the synthesis of essential hormones and pharmaceuticals. Its estrogenic activity, coupled with cholesterol-lowering properties, expands its applications to hormone therapies and cardiovascular health. 

Diosgenin’s versatility positions it as a key component in the pharmaceutical industry’s quest for innovative and natural solutions.

Where does it find use in?

Diosgenin finds extensive use in the pharmaceutical industry, particularly in the synthesis of hormones and corticosteroids. Its applications range from hormonal therapies to the production of essential pharmaceutical compounds, showcasing its significance in various healthcare formulations.

Exploring Diosgenin and its use in Pharmaceuticals, Health, and Drug Industry

Diosgenin Uses and Properties

The applications of Diosgenin are diverse, reflecting its versatile nature within the pharmaceutical and health sectors.

  1. Contraceptive Formulations: Diosgenin’s historical significance lies in its role as a precursor for progesterone, a key component in early combined oral contraceptive pills. The compound’s contribution to reproductive health underscores its importance in contraceptive formulations.
  2. Estrogenic Activity: In its unmodified state, Diosgenin exhibits estrogenic activity. This property opens avenues for applications in hormonal therapies, contributing to the development of treatments for conditions related to hormonal imbalances.
  3. Cholesterol Reduction: Diosgenin’s ability to reduce serum cholesterol levels adds another layer to its importance. As the world turns towards natural solutions for heart health, Diosgenin’s cholesterol-lowering properties become increasingly relevant.
  4. Corticosteroids and Sex Hormones Synthesis: Beyond reproductive and cardiovascular health, Diosgenin serves as a crucial precursor for the synthesis of corticosteroids and sex hormones. This includes the production of DHA and prednisolone, essential compounds with applications in anti-inflammatory and immunosuppressive therapies.
  5. DHEA, or Dehydroepiandrosterone Synthesis: DHEA is a precursor hormone produced by the adrenal glands, gonads, and the brain. It serves as a building block for the synthesis of various sex hormones, including estrogen and testosterone. DHEA levels typically peak in early adulthood and gradually decline with age.
  6. Diosgenin’s Transformation into DHEA:The journey from Diosgenin to DHEA involves a series of enzymatic conversions. Diosgenin, sourced from plants like Dioscorea, undergoes complex biochemical processes to eventually emerge as DHEA. This transformation highlights Diosgenin’s role not only in the creation of progesterone but also in the synthesis of a broader spectrum of hormones crucial for hormonal balance.

Significance of DHEA:

  1. Hormonal Balance: DHEA is a precursor for both estrogen and testosterone. As such, it plays a crucial role in maintaining hormonal balance, particularly in the context of age-related hormonal changes.
  2. Cognitive Function: Some studies suggest that DHEA may have a positive impact on cognitive function, potentially benefiting memory and overall brain health.
  3. Bone Density: DHEA has been linked to bone health, and adequate levels may contribute to maintaining optimal bone density.
  4. Anti-Inflammatory Effects: DHEA exhibits anti-inflammatory properties, which could have implications for conditions related to inflammation and immune system regulation.

Understanding Diosgenin’s involvement in the synthesis of DHEA sheds light on its significance not just as a precursor for specific hormones but as a contributor to the intricate web of hormonal regulation and overall health.

Diosgenin’s Role in 7 Keto DHEA Synthesis: 7 Keto DHEA is a metabolite of DHEA, a naturally occurring hormone produced by the adrenal glands. It holds significance due to its unique properties, particularly its role in metabolism and weight management. 

Unlike DHEA, 7 Keto DHEA does not convert into sex hormones like estrogen and testosterone. This characteristic makes it a safer alternative for individuals seeking the benefits of DHEA without the potential side effects associated with hormonal fluctuations.

Diosgenin as a Precursor: Diosgenin plays a critical role as a precursor in the synthesis of 7 Keto DHEA. The multi-step process involves the transformation of Diosgenin into DHEA, and subsequently, the conversion of DHEA into 7 Keto DHEA. This intricate biochemical journey highlights Diosgenin’s versatility and its contribution to the creation of compounds with distinct therapeutic properties.


Significance of 7 Keto DHEA

  1. Metabolism Boost: 7 Keto DHEA is renowned for its role in boosting metabolism. This property makes it a sought-after supplement for individuals looking to support weight loss and enhance overall metabolic function.
  2. Anti-Aging Potential: Studies suggest that 7 Keto DHEA may have anti-aging effects, potentially influencing factors such as skin health, cognitive function, and energy levels.
  3. Immune System Support: Some research indicates that 7 Keto DHEA may play a role in supporting the immune system, contributing to overall health and well-being.

By serving as a precursor for 7 Keto DHEA, Diosgenin becomes a key player in the realm of metabolic regulation and anti-aging interventions.

Other additional properties other than therapeutic uses

Aside from its therapeutic applications, Diosgenin possesses properties that contribute to its desirability in pharmaceutical manufacturing.

  1. Stability: Diosgenin exhibits stability under specific conditions, ensuring its suitability for incorporation into pharmaceutical formulations without compromising the integrity of the end product.
  2. Compatibility: Diosgenin’s compatibility with other pharmaceutical ingredients makes it a preferred choice for formulators seeking a versatile compound for various drug formulations.
  3. Purity: HimPharm’s Diosgenin is available in varying purities, ranging from 90 to 92% for standard applications to 95 to 98% for premium requirements. This emphasis on purity aligns with the pharmaceutical industry’s demand for high-quality active pharmaceutical ingredients (APIs).

The Raw Material from Which Diosgenin is Obtained

Raw Material Overview

What is the Raw Material (RM)?

The raw material for Diosgenin extraction is derived from specific plant sources, primarily Dioscorea species. Dioscorea, commonly known as wild yam or Chinese yam, serves as the reservoir for Diosgenin, the key compound sought after in pharmaceutical manufacturing.

Where is it found?

Dioscorea plants thrive in various regions globally, with specific species being more concentrated in regions like Asia and Africa. These regions provide the ideal climate and soil conditions for the growth of Dioscorea plants, ensuring a consistent and reliable source of raw material for Diosgenin extraction.

What is its botanical name?

The botanical name of Dioscorea varies depending on the species. Dioscorea opposita and Dioscorea villosa are examples of species commonly associated with Diosgenin extraction. The correct identification of these botanical sources is crucial to maintaining the integrity and quality of Diosgenin.

Alternative Sources of Raw Material for Diosgenin Extraction

While Dioscorea species are the primary sources of Diosgenin, ongoing research explores alternative plant sources with Diosgenin content. This diversification aims to ensure a stable supply chain and reduce dependence on specific plant species.

HimPharm Manufacturing Standards

HimPharm’s Role in Diosgenin Production

HimPharm, with a rich history dating back to 1979, has been at the forefront of Diosgenin production. As a leading manufacturer, HimPharm plays a crucial role in ensuring a sustainable and high-quality supply of Diosgenin to meet the demands of the pharmaceutical, drug manufacturing, and natural products industry.

Upholding International Quality Standards

HimPharm’s commitment to quality is exemplified through its adherence to international standards in Diosgenin production. The manufacturing processes employed by HimPharm undergo rigorous quality control measures to meet the stringent criteria set by global regulatory bodies.

HimPharm’s Commitment to Fulfilling Your Bulk Requirements for Diosgenin

Whether the demand is for Diosgenin in its standard purity range of 90 to 92% or the premium range of 95 to 98%, HimPharm stands ready to fulfill bulk requirements. The flexibility in purity levels caters to the diverse needs of pharmaceutical manufacturers, ensuring the availability of Diosgenin tailored to specific formulations and applications.

Diosgenin Production Processes

Step-by-Step Manufacturing Process

The manufacturing process of Diosgenin involves a series of meticulous steps to ensure the extraction and isolation of this vital compound.

  1. Extraction from Dioscorea Plants: The process commences with the extraction of Diosgenin from the tubers or roots of Dioscorea plants. This involves the use of solvents to isolate Diosgenin from the plant matrix.
  2. Purification: The extracted material undergoes purification to eliminate impurities and undesired components. This step is crucial in achieving the desired purity levels of Diosgenin.
  3. Crystallization: Diosgenin, in its purified form, undergoes a crystallization process. This step ensures the formation of Diosgenin crystals with defined characteristics, contributing to the compound’s physical stability.
  4. Drying: The final step involves drying the Diosgenin crystals to remove any residual moisture, resulting in a stable and ready-to-use pharmaceutical ingredient.

Testing in Diosgenin Manufacturing

Quality control is paramount in Diosgenin manufacturing, and HimPharm places a strong emphasis on comprehensive testing throughout the production process.

  1. Purity Analysis: Diosgenin undergoes rigorous purity analysis, ensuring that the final product meets the specified purity levels. This is critical for pharmaceutical formulations where the purity of active ingredients is non-negotiable.
  2. Contaminant Detection: HimPharm employs advanced techniques to detect and eliminate any contaminants that may compromise the quality of Diosgenin. This includes screening for heavy metals, residual solvents, and other impurities.
  3. Physical Characteristics: The physical characteristics of Diosgenin, including its appearance, particle size, and crystalline structure, are thoroughly examined to guarantee consistency and stability.

Navigating Production Bottlenecks in Diosgenin Manufacturing

While Diosgenin production is a well-established process, certain challenges may arise in large-scale manufacturing. These potential bottlenecks include:

  1. Raw Material Supply: Dependence on specific Dioscorea species for raw material can pose challenges in maintaining a stable supply chain. HimPharm’s extensive network of suppliers and ongoing research into alternative sources mitigate this risk.
  2. Extraction Efficiency: Achieving high extraction efficiency is crucial for optimizing Diosgenin yield. HimPharm addresses this by employing advanced extraction techniques and continuous process improvement.
  3. Quality Assurance: Ensuring consistent quality throughout large-scale production requires robust quality assurance measures. HimPharm’s experienced team and state-of-the-art equipment are instrumental in maintaining quality standards.

HimPharm’s Manufacturing Advantage

 How HimPharm Helps Overcome Challenges and Bottlenecks

HimPharm’s extensive experience in Diosgenin manufacturing positions it as a reliable partner for pharmaceutical companies navigating the complexities of large-scale production. The following factors highlight HimPharm’s manufacturing advantage:

  1. Long History and Expertise: With a history dating back to 1979, HimPharm brings decades of expertise to Diosgenin production. This longevity signifies a deep understanding of the industry and the ability to adapt to evolving challenges.
  2. Access to Genuine Raw Material: HimPharm’s century-long involvement in the herbs and herbal products trade provides it with unparalleled access to genuine and high-quality raw material. This ensures the integrity of the Diosgenin manufacturing process.
  3. Quality Assurance Team: HimPharm’s quality assurance team, equipped with modern testing facilities, plays a pivotal role in maintaining the promised quality of Diosgenin. Their expertise guides the manufacturing process to meet stringent standards.
  4. Scalability and Flexibility: HimPharm’s modern facility is designed for scalability, allowing it to handle manufacturing from small to very large batches. This scalability ensures the ability to meet demand surges while also offering flexibility in catering to smaller lot requirements.


Recap of the Key Insights 

Diosgenin, a natural steroid with diverse applications, stands at the forefront of pharmaceutical innovation. HimPharm’s commitment to quality and extensive manufacturing capabilities positions it as the ideal partner for sourcing Diosgenin, meeting the evolving needs of the pharmaceutical, drug manufacturing, and natural products industry.

Leveraging HimPharm’s Commitment to Quality and its Manufacturing Facility to Fulfill Your Demand for Top-Quality Diosgenin Requirements

As the pharmaceutical and natural products industry embraces the potential of Diosgenin, HimPharm emerges as a reliable source for high-quality Diosgenin. With a legacy of excellence, HimPharm invites businesses to explore the possibilities of incorporating Diosgenin into their formulations, backed by a commitment to quality and a manufacturing facility designed to meet diverse demands.

In the dynamic landscape of health, wellness, herbal medicine, and pharmaceuticals, Diosgenin serves as a cornerstone for innovative formulations. As businesses seek reliable partners in the procurement of essential pharmaceutical ingredients, HimPharm emerges as a beacon of trust and expertise.

The synthesis of Diosgenin involves a sophisticated process, balancing technical precision with a commitment to producing a compound of unparalleled purity. HimPharm’s manufacturing standards not only meet international benchmarks but exceed them, ensuring that every batch of Diosgenin aligns with the stringent requirements of the pharmaceutical industry.

Upholding International Quality Standards

HimPharm’s dedication to upholding international quality standards is evident in every stage of Diosgenin production. Stringent quality control measures are implemented to guarantee the consistency, purity, and efficacy of the final product. This commitment positions HimPharm as a preferred partner for pharmaceutical companies seeking excellence in their formulations.

The versatility of Diosgenin extends beyond its applications in hormonal therapies and cardiovascular health. As pharmaceutical companies explore the potential of Diosgenin in various therapeutic areas, HimPharm stands ready to cater to the evolving needs of the industry.

Scalability and Flexibility

HimPharm’s modern manufacturing facility is a testament to its commitment to scalability and flexibility. The ability to scale production seamlessly, from small to large batches, enables HimPharm to meet the demands of a dynamic market. Whether a client requires a consistent supply for a flagship product or a smaller batch for a specialized formulation, HimPharm’s flexibility ensures tailored solutions.

The scalability factor is particularly crucial in an industry where demand can experience sudden surges. HimPharm’s proactive approach to manufacturing positions it as a strategic partner for businesses that seek reliability, consistency, and the assurance of timely deliveries.

Meeting Bulk Requirements with Precision

Understanding the specific needs of pharmaceutical manufacturers, HimPharm extends its commitment to meeting bulk requirements with precision. Diosgenin is offered in varying purity levels – 90 to 92% for standard applications and 95 to 98% for those requiring a premium standard. This adaptability allows clients to choose the purity level that aligns with their formulation requirements.

The emphasis on purity is paramount in the pharmaceutical industry, where the efficacy and safety of formulations depend on the quality of active pharmaceutical ingredients. HimPharm’s Diosgenin, meeting the highest purity standards, ensures that pharmaceutical companies can create formulations with confidence.

Navigating Complexities and Challenges

The production of Diosgenin, like any sophisticated manufacturing process, comes with its complexities and challenges. HimPharm, drawing on its decades-long experience, possesses a deep understanding of these challenges and has developed strategies to navigate them seamlessly.

Raw Material Supply Assurance

One challenge in Diosgenin production is the dependence on specific Dioscorea species for raw material. However, HimPharm’s extensive network of suppliers, combined with ongoing research into alternative sources, ensures a robust and secure raw material supply chain. This forward-thinking approach mitigates the risks associated with fluctuations in raw material availability.

Extraction Efficiency Optimization

Achieving high extraction efficiency is critical for optimizing Diosgenin yield. HimPharm employs advanced extraction techniques and continually improves its processes to enhance efficiency. This commitment ensures a consistent and reliable supply of Diosgenin, meeting the demands of pharmaceutical manufacturers without compromising on quality.

Quality Assurance Excellence

Maintaining consistent quality throughout large-scale production requires a robust quality assurance team and state-of-the-art equipment. HimPharm’s quality assurance team, with their extensive expertise, plays a pivotal role in upholding the promised quality of Diosgenin. Their vigilance ensures that every batch meets and exceeds industry standards.

Conclusion: Leveraging HimPharm’s Expertise for Diosgenin Requirements

In conclusion, Diosgenin emerges not just as a compound but as a catalyst for innovation in the pharmaceutical and natural products industry. HimPharm, with its rich history, cutting-edge manufacturing facility, and unwavering commitment to quality, invites businesses to leverage its expertise in sourcing top-quality Diosgenin.

The journey from Dioscorea plants to the final crystalline Diosgenin involves precision, dedication, and a relentless pursuit of excellence. HimPharm positions itself as a strategic partner, offering not just a product but a collaborative approach to fulfilling Diosgenin requirements.

As businesses navigate the evolving landscape of health, wellness, and pharmaceuticals, HimPharm stands ready to be the reliable source they can depend on. Diosgenin, with its myriad applications, finds a home in formulations that aim not just for therapeutic efficacy but for a touch of nature’s precision.

Explore the potential of Diosgenin with HimPharm, where quality meets innovation, and reliability is a promise kept. The journey towards groundbreaking formulations begins with a partner committed to your success – HimPharm, your gateway to excellence in Diosgenin sourcing.

Write to or Call HimPharm to Request a Quote, COA, and MSDS.


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