Hypericum Perforatum extract

St. John's Wort Extract

Written by

Reviewed by

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Gaurav Sood

Partner - HimPharm

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Dr B M Sood

Chairman - HimPharm

Hypericum Perforatum Extract or Hypericin by HimPharm

Category: Phytochemical
Trade Names: None (Often sold as St. John’s Wort Extract)
Routes of Administration: Oral, Topical
ATC Code: Not Applicable


  • CAS Number: 548-04-9
  • PubChem CID: 5281079
  • ChemSpider ID: 4445116

Chemical and Physical Data

  • Molecular Formula C30H16O8
    Molar Mass 504.44 g/mol

SMILES: C1=CC(=CC=C1C2=CC(=O)C3=C(C=C(C=C3O2)O)O)C4=CC(=C(C=C4)C5=CC6=C(C=C5)C(=O)C7=C(C6=O)C=C(C=C7)O)O

InChI: InChI=1S/C30H16O8/c31-13-7-19-23(11-13)37-29(35)21-5-1-17-9-25(41-27(17)15-3-19)26-10-18(2-6-22(26)30(21)36)28-16-4-14(32)8-20(33)12-16/h1-12,31-34H


What is Hypericum Perforatum Extract or Hypericin?

Hypericum perforatum extract, commonly known as St John’s wort, is derived from the plant Hypericum perforatum. This herbal extract is renowned for its diverse range of active constituents, notably hypericin and hyperforin. Hypericin, a red anthraquinone-derivative, and hyperforin, a phloroglucinol derivative, are the principal active compounds responsible for the therapeutic properties of Hypericum perforatum.

Hypericin Hypericum Perforatum extract

Impact of Hypericum Perforatum Extract on Pharmaceutical, Drug, and Natural Products Industry

The significance of Hypericum perforatum extract extends across various industries, particularly in pharmaceuticals, healthcare, and the natural products sector. Its reputation as a herbal treatment for depression has fueled extensive research, and its active components have shown potential for treating alcoholism and exhibiting antibacterial properties against gram-negative bacteria. 

Understanding the impact of this extract is crucial for businesses operating in health, wellness, herbal medicine, nutraceuticals, and pharmaceutical sectors.

Understanding Hypericum Perforatum Extract

What is Hypericum Perforatum Extract?

Hypericum perforatum extract is a botanical preparation derived from the flowering tops of Hypericum perforatum, commonly known as St John’s wort. This extract contains a rich array of bioactive compounds, with hypericin and hyperforin being the most prominent. 

These compounds contribute to the extract’s therapeutic properties, making it a valuable resource in various applications.

Applications and Uses of Hypericum Perforatum Extract, Hypericin uses

The applications of Hypericum perforatum extract are diverse, ranging from traditional medicine to modern pharmaceuticals. Its historical use dates back to at least the first century AD, where it was considered a cure-all or panacea. 

In contemporary times, it has garnered attention for its potential as an antidepressant, supported by numerous studies and clinical trials. The extract’s versatility makes it a sought-after ingredient in health supplements, herbal teas, and cosmetics.

Physical Characteristics: What Does Hypericum Perforatum Extract Look Like?

Hypericum perforatum extract exhibits various physical characteristics, depending on factors such as extraction methods and plant variations. In its concentrated form, it may appear as a red-colored liquid due to the presence of hypericin. 

The extract’s appearance can range from oily to powdery, depending on the processing techniques employed. Understanding these physical characteristics is vital for businesses involved in the manufacturing and formulation of products containing this extract.

Sourcing and Processing: Where Does It Come From, and How Is It Obtained or Processed?

The sourcing and processing of Hypericum perforatum extract require careful consideration. The plant is cultivated in different regions, and the concentration of active compounds can vary. Extraction methods, such as oil extraction from glands or grinding above-ground parts into powder, play a crucial role in obtaining the desired properties. 

Businesses in the health and wellness industry must be aware of these sourcing and processing nuances to ensure the quality of their end products.

Importance of Hypericum Perforatum Extract

The importance of Hypericum perforatum extract lies in its therapeutic potential and versatile applications. As a natural remedy for depression and other health conditions, it offers a holistic approach to wellness. 

Its significance is underscored by the growing consumer interest in herbal and plant-based solutions, making it a valuable asset for businesses looking to cater to the evolving preferences of health-conscious consumers.

Diverse Applications: Where Does It Find Use?

Hypericum perforatum extract finds use across various industries, each harnessing its unique properties. In traditional medicine, it has been employed as a cure-all, while modern studies highlight its efficacy as an antidepressant. 

The extract’s applications extend to herbal teas, cosmetics, and health supplements, showcasing its versatility. For businesses in the health and wellness sector, understanding the diverse applications of Hypericum perforatum extract opens doors to innovative product formulations.

Exploring Hypericum Perforatum Extract in Pharmaceuticals and Health Industry

Therapeutic Uses and Properties of Hypericum Perforatum Extract

The therapeutic uses of Hypericum perforatum extract are well-documented, with a primary focus on its antidepressant properties. Studies and clinical trials have consistently shown its efficacy in treating mild to moderate depression. 

The active compounds, hypericin, and hyperforin contribute to the extract’s mood-enhancing effects. The extract’s potential extends beyond depression, with research indicating its usefulness in addressing alcoholism and exhibiting antibacterial properties against gram-negative bacteria.

List of Hypericin Uses and Explanations for Specific End Uses

The list of uses for Hypericum perforatum extract is extensive and caters to a range of health and wellness needs. Hypericum perforatum benefits. Here’s a breakdown of specific end uses and explanations:

  • Depression Treatment: Numerous studies and meta-analyses support the efficacy of Hypericum perforatum extract in treating depression. It has been found to be as effective as standard antidepressant pharmaceuticals, with fewer adverse effects. The extract’s impact on mood regulation makes it a promising natural solution for individuals experiencing depressive symptoms.
  • Alcoholism Management: Hyperforin, a constituent chemical in Hypericum perforatum, shows potential in the treatment of alcoholism. Research suggests that this compound may contribute to reducing alcohol dependence. Businesses in the pharmaceutical and healthcare sectors can explore the development of products targeting alcoholism management with the inclusion of Hypericum perforatum extract.
  • Antibacterial Properties: The extract has demonstrated antibacterial properties, particularly against gram-negative bacteria. This characteristic makes it a valuable component in formulations aimed at addressing bacterial infections. Pharmaceutical companies can leverage this property to develop antimicrobial products.

Additional Properties Beyond Therapeutic Uses

Beyond its well-established therapeutic uses, Hypericum perforatum extract possesses additional properties that enhance its appeal in various industries:

  • Natural Ingredient in Cosmetics: The extract’s antioxidant and anti-inflammatory properties make it suitable for inclusion in cosmetic formulations. Skincare and cosmetic companies can utilize Hypericum perforatum extract for its potential to promote skin health and soothe irritated skin.
  • Herbal Teas and Dietary Supplements: Recognized for its traditional use in herbal teas, Hypericum perforatum extract is a favored ingredient in the production of health-promoting teas. Additionally, it serves as a key component in dietary supplements, offering a natural source of bioactive compounds that support overall well-being.

The Raw Material for Hypericum Perforatum Extract: Natural Source

Raw Material Overview

What is the Raw Material?
The raw material for Hypericum perforatum extract is derived from the flowering tops of the Hypericum perforatum plant, commonly known as St John’s wort. These tops contain a rich concentration of active compounds, including hypericin and hyperforin, which contribute to the extract’s therapeutic properties.

Where Is It Found?
Hypericum perforatum is native to Europe but has been naturalized in other regions, including North America and parts of Asia. The plant thrives in sunny, well-drained areas and is often found in meadows, fields, and along roadsides.

What Is Its Botanical Name?
The botanical name of Hypericum perforatum underscores its genus (Hypericum) and species (perforatum). This nomenclature is essential for botanical identification and ensures the sourcing of the correct plant material for extraction.

Exploring Alternative Sources of Raw Material for Extracting Hypericum Perforatum Extract

While Hypericum perforatum is the primary source for obtaining the raw material, exploring alternative sources is a consideration for industries seeking a diversified supply chain. Businesses may explore cultivation practices and potential variants of Hypericum species to ensure a consistent and sustainable raw material supply.

HimPharm Manufacturing Standards

Role of HimPharm in Hypericum Perforatum Extract Production

HimPharm plays a pivotal role in the production of Hypericum perforatum extract, contributing its expertise in manufacturing high-quality Active Pharmaceutical Ingredients (APIs). With a history dating back to 1979, HimPharm brings decades of experience to the herbal products and pharmaceutical industry.

Upholding International Quality Standards in Manufacturing
Quality assurance is a cornerstone of HimPharm’s manufacturing processes. With a profound Quality Assurance team equipped with state-of-the-art facilities, HimPharm ensures that its Hypericum perforatum extract meets international quality standards. This commitment to quality extends to every stage of production, from raw material sourcing to the final product.

HimPharm’s Commitment to Fulfilling Bulk Requirements for Hypericum Perforatum Extract

HimPharm’s manufacturing capabilities are geared towards meeting bulk requirements for Hypericum perforatum extract. The company’s modern facility is adept at scaling production from small to large batches, providing businesses with flexibility and ensuring timely delivery even during demand surges.

Hypericum Perforatum Extract Production Processes

Step-by-Step Details of Manufacturing Hypericum Perforatum Extract

The production of Hypericum perforatum extract involves several key steps, each contributing to the quality and efficacy of the final product:

  1. Harvesting: The flowering tops of Hypericum perforatum are carefully harvested, ensuring the optimal time for maximum active compound content.
  2. Drying: The harvested material undergoes a drying process to reduce moisture content, preserving the integrity of the active compounds.
  3. Extraction: Various extraction methods, such as oil extraction or powdering, are employed to obtain the desired bioactive compounds.
  4. Purification: The extracted material undergoes purification processes to isolate specific compounds, ensuring a standardized and high-quality extract.

Testing in Hypericum Perforatum Extract Manufacturing: Considerations for Manufacturers

Quality control is integral to the manufacturing of Hypericum perforatum extract. HimPharm employs rigorous testing procedures throughout the production process to validate the concentration of active compounds and ensure adherence to quality standards. Manufacturers utilizing HimPharm’s Hypericum perforatum extract can be confident in the consistency and reliability of the raw material.

Navigating Production Bottlenecks in Hypericum Perforatum Extract Manufacturing

While production bottlenecks can be common in the manufacturing industry, HimPharm’s experience and advanced facilities enable the company to navigate challenges effectively. The company’s commitment to overcoming bottlenecks ensures a seamless manufacturing process, providing clients with a reliable and uninterrupted supply of Hypericum perforatum extract.

HimPharm’s Manufacturing Advantage

Overcoming Challenges and Bottlenecks

HimPharm’s manufacturing advantage lies in its ability to overcome challenges and bottlenecks through a combination of experience, advanced technology, and a commitment to quality. The company’s flexibility in handling both small and large batches positions it as a reliable partner for businesses in need of Hypericum perforatum extract for various applications.

Hypericum perforatum St John's Wort


Recap of Key Insights

In conclusion, Hypericum perforatum extract emerges as a versatile and valuable resource in the pharmaceutical, healthcare, and natural products industries. 

Its therapeutic uses, diverse applications, and the commitment of HimPharm to uphold quality standards make it a compelling choice for businesses seeking high-quality Hypericum perforatum extract.

Leveraging HimPharm’s Commitment to Quality and Its Manufacturing Facility to Fulfill Top-Quality Hypericum Perforatum Extract Requirements

Businesses looking to incorporate Hypericum perforatum extract in their products can leverage HimPharm’s commitment to quality and its state-of-the-art manufacturing facility. 

Whether for depression treatment, alcoholism management, or cosmetic formulations, HimPharm stands as a reliable source for top-quality Hypericum perforatum extract.

Write to or Call HimPharm to Request a Quote, COA, and MSDS.


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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.



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