Methoxsalen USP
Methoxsalen BP
Methoxsalene, 8-MOP

Written by

Reviewed by

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Gaurav Sood

Partner - HimPharm

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Dr B M Sood

Chairman - HimPharm

Methoxsalen by HimPharm

Category: Phytochemical
Trade Names: Oxsoralen, 8-Methoxypsoralen, 8-MOP.
Routes of Administration: Oral, Topical
ATC Code: D05B


  • CAS Number: 298-81-7
  • PubChem CID: 4114
  • ChemSpider ID: 3970

Chemical and Physical Data

  • Molecular Formula C12H8O4
  • Molar Mass 216.19 g/mol


InChI: InChI=1S/C12H8O4/c1-15-9-5-4-7(6-10(9)16-2)3-8-11(13)12(14)17-8/h3-6,13H,1-2H3



Methoxsalen, also known by its brand name Oxsoralen, is a crucial medication employed in the treatment of various skin conditions, including psoriasis, eczema, vitiligo, and certain cutaneous lymphomas. It operates synergistically with ultraviolet (UVA) light, either from lamps or sunlight, to modify the way skin cells receive UVA radiation, effectively addressing these dermatological disorders. 

The below information dives into the many aspects of Methoxsalen, shedding light on its origins, applications, and the pivotal role it plays in enhancing the health and wellness industry.


Impact of Methoxsalen on the Pharmaceutical, Drug, and Natural Products Industry

The impact of Methoxsalen on the pharmaceutical, drug, and natural products industry is huge. By harnessing the therapeutic potential of Methoxsalen in treating skin conditions, it has become a cornerstone in dermatological care. 

The integration of Methoxsalen into therapeutic protocols has revolutionized the approach to conditions like psoriasis and vitiligo, offering patients an effective remedy. 

The collaboration between Methoxsalen and UVA light presents a unique avenue for addressing these ailments, making it a staple in the toolkit of healthcare providers globally.

Understanding Methoxsalen

What is Methoxsalen?

Methoxsalen belongs to a class of organic natural molecules known as furanocoumarins, characterized by the fusion of coumarin with furan. Isolated in 1947 under the name “ammoidin” from the plant Ammi majus, Methoxsalen’s discovery marked a pivotal moment in dermatological therapy. 

Beyond its historical significance, Methoxsalen’s chemical structure and properties make it a versatile player in addressing various skin conditions.

Uses of Methoxsalen

The applications of Methoxsalen extend beyond its chemical composition. Primarily used in conjunction with UVA light exposure, Methoxsalen finds its place in treating psoriasis, eczema, vitiligo, and cutaneous lymphomas. 

The synergy between Methoxsalen and UVA radiation modifies the response of skin cells, offering a targeted approach to managing these dermatological challenges. This dual therapy has become a standard in the dermatologist’s arsenal, providing relief to patients affected by these conditions.

Physical Characteristics of Methoxsalen

Methoxsalen, in its physical form, is a crystalline compound with a molecular formula of C12H8O4. Its characteristic appearance is a testament to the precision required in pharmaceutical manufacturing. The meticulous attention to detail in producing Methoxsalen ensures its purity and efficacy in therapeutic applications.

Source and Extraction Process of Methoxsalen

The origins of Methoxsalen can be traced back to the plant kingdom, specifically Ammi majus, commonly known as bishop’s weed. The extraction process involves isolating Methoxsalen from the plant’s components, emphasizing the importance of botanical sources in pharmaceutical manufacturing. 

This natural derivation aligns with the growing trend towards plant-based therapies in the health and wellness industry.

Importance of Methoxsalen

Methoxsalen’s significance lies in its ability to address challenging dermatological conditions effectively. As a key player in phototherapy, Methoxsalen contributes to the broader landscape of natural and targeted interventions. Its importance is further underscored by its versatile applications, offering relief to individuals grappling with psoriasis, eczema, vitiligo, and cutaneous lymphomas.

Diverse Applications of Methoxsalen

Beyond its primary applications in dermatology, Methoxsalen has found utility in various industries. Its incorporation into pharmaceutical formulations showcases its adaptability as an active pharmaceutical ingredient (API). 

Moreover, Methoxsalen’s potential extends to cosmetic applications, aligning with the broader trend of harnessing natural compounds for skincare and wellness products.

Exploring Methoxsalen and its Use in Pharmaceuticals, Health, and Drug Industry

Methoxsalen Uses and Properties

The uses of Methoxsalen span across diverse therapeutic applications, making it a versatile compound in the pharmaceutical, health, and drug industries. Its primary role lies in the treatment of psoriasis, eczema, vitiligo, and cutaneous lymphomas. 

The modulating effect on UVA radiation provides a targeted approach to managing these skin conditions, offering patients a reliable and effective solution.

Various Uses of Methoxsalen Explained

  • Psoriasis: Methoxsalen’s interaction with UVA light helps alleviate the symptoms of psoriasis by slowing down the excessive growth of skin cells. This targeted approach minimizes the characteristic red patches and silvery scales associated with psoriasis, enhancing the quality of life for affected individuals.
  • Eczema: In eczema, Methoxsalen contributes to controlling inflammation and reducing the persistent itching commonly experienced by individuals with this skin condition. The combination of Methoxsalen and UVA light provides relief by addressing the underlying factors contributing to eczematous reactions.
  • Vitiligo: Methoxsalen’s role in treating vitiligo involves repigmenting the affected areas of the skin. By selectively affecting pigmented cells, Methoxsalen assists in restoring skin color, fostering a more uniform complexion for individuals dealing with vitiligo.
  • Cutaneous Lymphomas: Methoxsalen’s application extends to certain cutaneous lymphomas, a group of non-Hodgkin lymphomas that primarily involve the skin. The targeted effect on skin cells under UVA exposure aids in managing the symptoms associated with these lymphomas.

Additional Properties of Methoxsalen

In addition to its therapeutic uses, Methoxsalen possesses other noteworthy properties that contribute to its significance in the pharmaceutical and health sectors:

  • Cosmetic Formulations: Methoxsalen has found its way into cosmetic formulations, capitalizing on its skin-friendly properties. The compound’s potential to interact with UVA light makes it a valuable ingredient in skincare products, aligning with the growing demand for natural and effective cosmetic solutions.
  • Research and Development: Methoxsalen’s unique properties make it an interesting subject for ongoing research and development. Scientists explore its potential applications in various medical fields, including dermatology, oncology, and regenerative medicine.

The Raw Material from Which Methoxsalene is Obtained

Overview of Methoxsalene Raw Material

Raw Material Overview

  1. What is the Raw Material? The raw material for Methoxsalen is derived from the plant Ammi majus, commonly known as bishop’s weed. This botanical source serves as the foundation for Methoxsalen production, emphasizing the importance of natural origins in pharmaceutical manufacturing.
  2. Where is it Found? Ammi majus is native to regions with temperate climates, and its cultivation provides a sustainable source of the raw material for Methoxsalen. The careful sourcing of this botanical material ensures the consistent quality of Methoxsalen in pharmaceutical formulations.
  3. Botanical Name of the Raw Material The botanical name of the raw material is Ammi majus, and its recognition as a reliable source of Methoxsalen underscores the significance of botanical diversity in pharmaceutical sourcing.

Alternative Sources for Extracting Methoxsalen

While Ammi majus remains the primary source for Methoxsalen, ongoing research explores alternative botanical sources. These alternatives aim to enhance sustainability and diversify the sources of Methoxsalen, aligning with the industry’s commitment to responsible and eco-friendly practices.

HimPharm Manufacturing Standards

HimPharm's Role in Methoxsalen Production

HimPharm plays a pivotal role in the production of Methoxsalen, leveraging decades of experience in the pharmaceutical and herbal product manufacturing industry. Established in 1979, HimPharm has become synonymous with quality, reliability, and innovation. 

The company’s commitment to excellence extends to every stage of Methoxsalen production, from raw material sourcing to final product formulation.

Upholding International Quality Standards

HimPharm’s manufacturing standards adhere to international benchmarks, ensuring that every batch of Methoxsalen meets stringent quality criteria. The company’s dedication to upholding these standards is underscored by its state-of-the-art facilities, equipped with cutting-edge technology and staffed by a team of experienced professionals. 

This commitment ensures that Methoxsalen produced by HimPharm consistently exceeds industry quality expectations.

HimPharm's Commitment to Fulfilling Bulk Requirements for Methoxsalen

HimPharm takes pride in its ability to fulfill bulk requirements for Methoxsalen, catering to the demands of pharmaceutical companies, trading agents, and industrial bulk consumers. The company’s modern facility is designed to handle production at various scales, from small batches to large volumes, providing flexibility to clients with diverse needs. 

HimPharm’s efficient production processes and robust supply chain management contribute to on-time delivery, a crucial factor for clients in the pharmaceutical industry.

Methoxsalen Production Processes

Step-by-Step Manufacturing Process of Methoxsalen

The manufacturing process of Methoxsalen involves several intricate steps, each crucial to ensuring the compound’s purity and efficacy. These steps include:

  1. Raw Material Processing: The journey begins with the careful processing of raw materials, primarily sourced from Ammi majus. The botanical material undergoes stringent quality checks to guarantee its authenticity and potency.
  2. Extraction of Methoxsalen: The extraction process is a critical phase where Methoxsalen is isolated from the raw material. This step demands precision and adherence to strict protocols to obtain a high-quality extract.
  3. Purification: The extracted Methoxsalen undergoes a purification process to eliminate impurities, ensuring the final product meets the highest standards of pharmaceutical purity.
  4. Formulation: The purified Methoxsalen is then formulated into the desired pharmaceutical dosage form, whether it be oral, topical, or injectable, depending on the intended use.

Testing in Methoxsalen Manufacturing

Quality control is extremely important in Methoxsalen manufacturing. Rigorous testing protocols are implemented at every stage of production. This includes testing the raw material, monitoring the extraction process, and conducting thorough analyses on the final formulated product. 

These tests guarantee the potency, safety, and consistency of Methoxsalen, meeting regulatory requirements and surpassing industry expectations.

Navigating Production Bottlenecks in Methoxsalen Manufacturing

Despite the meticulous planning and advanced technology, challenges can arise in the manufacturing process. Common bottlenecks include variations in raw material quality, process deviations, and unexpected equipment failures. However, HimPharm’s experienced team and well-established quality assurance protocols are designed to swiftly address and overcome these challenges, ensuring a seamless production flow.

HimPharm’s Manufacturing Advantage: Overcoming Challenges and Bottlenecks

HimPharm’s manufacturing advantage lies in its ability to navigate challenges and bottlenecks effectively. The company’s commitment to continuous improvement and investment in research and development enables them to stay ahead of industry challenges. 

Whether it’s optimizing production processes or implementing innovative solutions, HimPharm remains agile in overcoming obstacles, ensuring uninterrupted Methoxsalen production.

ammi majus


Recap of Key Insights

In recapitulation, Methoxsalen emerges as a pivotal component in the treatment of dermatological conditions, offering a targeted and effective approach when combined with UVA light. Its uses extend beyond traditional pharmaceutical applications, finding a place in cosmetic formulations and ongoing research initiatives. 

HimPharm, with its extensive experience and commitment to quality, stands as a reliable source for Methoxsalen production, meeting the diverse needs of pharmaceutical companies, traders, and industrial consumers.

Leveraging HimPharm’s Commitment to Quality and Manufacturing Capabilities

As we conclude, it’s essential to emphasize the significance of choosing HimPharm as a partner in Methoxsalen sourcing. The company’s unwavering commitment to quality, international manufacturing standards, and the ability to fulfill bulk requirements position HimPharm as a leader in the industry. 

Clients can leverage HimPharm’s state-of-the-art facilities, experienced team, and flexibility in production to meet their specific Methoxsalen needs with confidence.

Write to or Call HimPharm to Request a Quote, COA, and MSDS.


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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.


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