Podophyllum Resin

Podophyllin Hexandrum
Podophyllin Emodi
Podophyllum Resin BP

Written by

Reviewed by

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Gaurav Sood

Partner - HimPharm

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Dr B M Sood

Chairman - HimPharm

Podophyllum Resin by HimPharm

Category: Phytochemical
Trade Names: Podophyllin
Routes of Administration: Topical
ATC Code: Not Applicable

Identifiers

  • CAS Number: 9000-55-9
  • PubChem CID: 5281391
  • ChemSpider ID: 4445265

Chemical and Physical Data

  • Molecular Formula C22H22O8
  • Molar Mass 414.41 g/mol

SMILES: COC1=CC2=C(C(=C1)[C@@H]3[C@@H]2[C@H]4C@HC5=C3C(=C(C=C5)O)O)OCO

InChI: InChI=1S/C22H22O8/c1-25-16-7-11(8-17(26-2)21(16)27-3)15-12-5-9(23)6-13-18(12)28-22(24)19(15)20(13)29-14-4-10(15)30-14/h5-8,14,19-20,23-24H,4H2,1-3H3/t14-,19-,20+/m0/s1

Introduction

Podophyllin Hexandrum

Podophyllin Hexandrum, also known as Podophyllin Emodi or Podophyllum resin BP, is a potent medicinal substance derived from the rhizome of the Himalayan Mayapple plant (Podophyllum hexandrum). This unique botanical extract has been a focal point in herbal medicine for its diverse applications, ranging from treating gastrointestinal issues to addressing skin conditions.

In its raw form, Podophyllin Hexandrum is a resin that contains active principles, including the prominent podophyllotoxin, along with inert materials. Renowned for its slow but drastic purgative effects, this compound finds applications in various therapeutic formulations.

Podophyllum Resin BP

Impact of Podophyllin Hexandrum on Pharmaceutical, Drug, and Natural Products Industry

The impact of Podophyllin Hexandrum on the pharmaceutical, drug, and natural products industry is profound. Its unique properties make it a valuable ingredient in the formulation of medications and healthcare products. 

The significance lies in its ability to act as a purgative, addressing severe cases of constipation and serving as an anthelmintic agent against intestinal worms.

Moreover, Podophyllin Hexandrum has found applications in dermatology, where podophyllotoxin serves as a precursor in the production of semisynthetic topoisomerase inhibitors, used in the treatment of various cancers. 

Its role in addressing genital warts, mouth and tongue sores related to HIV, and certain skin cancers further highlights its versatility.

Understanding Podophyllin Hexandrum

What is Podophyllin Hexandrum?

Podophyllin Hexandrum, also known as Podophyllum resin BP, is derived from the rhizome of the Himalayan Mayapple plant (Podophyllum hexandrum). This perennial herbaceous plant is indigenous to the Himalayan region and thrives in temperate climates with moist, well-drained soil. 

The rhizome, or underground stem, of the plant serves as the primary source of the resinous material containing podophyllin, the active compound sought after for its medicinal properties.

The botanical name of the Himalayan Mayapple plant is Podophyllum hexandrum, reflecting its classification within the plant kingdom. This plant species has been revered for centuries in traditional medicine systems for its therapeutic properties, particularly in the treatment of various ailments ranging from gastrointestinal disorders to skin conditions.

Uses of Podophyllin Hexandrum
Podophyllin Hexandrum is employed as a drastic but slow-acting purgative, capable of inducing acute inflammation of the stomach and intestines with violent peristaltic contractions in large doses. It contains the active principles of podophyllum, primarily podophyllotoxin, along with inert material. 

This unique combination makes it effective in severe cases of habitual constipation and as an anthelmintic agent to remove ankylostoma and other intestinal worms.

In pharmaceutical formulations, Podophyllum Resin powder is often administered in pill form, combined with extract of henbane or belladonna to prevent griping. Combinations with nux vomica, aloes, colocynth, or rhubarb are also common. A tincture of podophyllum resin, known as Tinctura Podophyllin, is prepared for specific applications.

Physical Characteristics of Podophyllin Hexandrum
Podophyllin Hexandrum, in its natural state, presents as a resinous substance with a distinct physical appearance. The resin is generally dark in color, reflecting the concentration of active compounds. Its texture can vary from semi-solid to solid, depending on factors such as temperature and processing methods.

The aroma of Podophyllin Hexandrum is characteristic, often described as earthy and herbal. Its taste can be bitter, contributing to its traditional use as a purgative. The physical characteristics of this resin play a crucial role in its formulation into different pharmaceutical products, ensuring optimal efficacy and patient compliance.

Source and Processing of Podophyllin Hexandrum
The primary source of Podophyllin Hexandrum is the rhizome of the Himalayan Mayapple plant. The extraction process involves carefully selecting and preparing high-quality rhizomes to ensure the potency and purity of the raw material. The extraction is typically carried out using solvent-based techniques to isolate bioactive compounds, with a focus on obtaining a high yield of podophyllotoxin.

The extracted material then undergoes purification processes to remove impurities and unwanted substances, ensuring the final product meets stringent quality standards. Concentration follows, enhancing the potency and efficacy of active compounds, particularly podophyllotoxin. The concentrated extract is further formulated into various pharmaceutical forms, such as powders, solutions, and ointments, depending on intended applications.

Significance of Podophyllin Hexandrum
Podophyllin Hexandrum holds significant therapeutic value in the treatment of various medical conditions. Its purgative properties make it a valuable agent in addressing severe cases of constipation and intestinal worms. Additionally, its role in dermatology and oncology underscores its diverse applications in modern medicine.

The unique composition of Podophyllin Hexandrum, particularly the presence of podophyllotoxin, contributes to its pharmacological activity and clinical efficacy. Ongoing research continues to explore its potential in new therapeutic areas, further highlighting its importance in pharmaceutical and healthcare industries.

Diverse Applications of Podophyllin Hexandrum
The applications of Podophyllin Hexandrum span across multiple therapeutic areas, reflecting its versatility and pharmacological properties. In gastroenterology, it is utilized as a potent purgative, capable of inducing bowel movements and relieving constipation. Its anthelmintic properties make it effective in expelling intestinal worms, offering relief from parasitic infections.

In dermatology, Podophyllin Hexandrum finds applications in the treatment of various skin conditions, including genital warts caused by human papillomavirus (HPV). Podophyllotoxin, a key component of Podophyllin Hexandrum, serves as a precursor in the production of semisynthetic compounds used in cancer therapy, highlighting its role in oncology.

History of Podophyllin Hexandrum
The history of Podophyllin Hexandrum dates back centuries, with its use documented in traditional medicine systems across different cultures. Indigenous communities in the Himalayan region recognized the medicinal properties of the Himalayan Mayapple plant and utilized its rhizome extract for various ailments.

The introduction of Podophyllin Hexandrum or Podophyllin Emodi to Western medicine occurred during the 19th century, as explorers and botanists brought back samples of the Himalayan Mayapple plant to Europe and North America. Its purgative and anthelmintic properties captured the interest of physicians, leading to its integration into pharmacopeias and medical practice.

Exploring Podophyllin Hexandrum and Its Use in Pharmaceuticals, Health, and Drug Industry

Uses and Properties of Podophyllin Hexandrum

Podophyllin Hexandrum possesses a range of therapeutic properties that contribute to its widespread use in pharmaceuticals, healthcare, and the drug industry. Its primary uses include:

  • Purgative: Podophyllin Hexandrum acts as a potent purgative, stimulating bowel movements and promoting intestinal cleansing. This property makes it valuable in treating constipation and maintaining gastrointestinal health.
  • Anthelmintic: The anthelmintic properties of Podophyllin Hexandrum make it effective in expelling intestinal worms, including ankylostoma and other parasitic infections.
  • Dermatological Applications: Podophyllin Hexandrum is utilized in dermatology for the treatment of various skin conditions, such as genital warts caused by human papillomavirus (HPV). Its topical application helps in the removal of warts and promotes skin healing.
  • Oncological Applications: Podophyllotoxin, a key component of Podophyllin Hexandrum, serves as a precursor in the production of semisynthetic compounds used in cancer therapy. These compounds exhibit cytotoxic effects on cancer cells, making them valuable in the treatment of certain malignancies.

Detailed Applications and Action Mechanism

The applications of Podophyllin Hexandrum are diverse, owing to its pharmacological properties and mechanism of action. In gastrointestinal disorders, it acts by:

  • Stimulating Peristalsis: Podophyllin Hexandrum stimulates peristalsis in the gastrointestinal tract, promoting bowel movements and facilitating the expulsion of fecal matter.
  • Increasing Secretions: It increases the secretion of fluids in the intestines, softening stool and easing bowel movements.
  • Inducing Inflammation: Podophyllin Hexandrum induces mild inflammation of the intestinal mucosa, triggering reflex contractions and facilitating the passage of stool.

In dermatological conditions, Podophyllin Hexandrum exerts its effects by:

  • Causing Necrosis: Topical application of Podophyllin Hexandrum leads to necrosis of affected tissues, including genital warts. This process helps in the removal of warts and prevents their recurrence.
  • Inhibiting Viral Replication: Podophyllin Hexandrum inhibits the replication of human papillomavirus (HPV) in infected cells, reducing the spread and recurrence of genital warts.

In oncology, Podophyllin Hexandrum derivatives act by:

  • Targeting Cancer Cells: Semisynthetic compounds derived from podophyllotoxin target cancer cells by disrupting microtubule function and inducing apoptosis.
  • Inhibiting DNA Topoisomerases: Podophyllotoxin derivatives inhibit DNA topoisomerases, enzymes crucial for DNA replication and cell division in cancer cells.

Additional Properties Beyond Therapeutic Uses

Beyond its therapeutic applications, Podophyllin Hexandrum exhibits additional properties that contribute to its value in pharmaceuticals and healthcare:

  • Antimicrobial Activity: Podophyllin Emodi possesses antimicrobial properties, inhibiting the growth of bacteria and fungi. This property is useful in preventing infections and promoting wound healing.
  • Anti-inflammatory Effects: Podophyllin Hexandrum exhibits anti-inflammatory effects, reducing inflammation and swelling associated with certain skin conditions and gastrointestinal disorders.
  • Antioxidant Properties: Podophyllin Hexandrum contains antioxidants that scavenge free radicals and protect cells from oxidative damage. This property contributes to its overall health benefits and therapeutic efficacy.

The diverse properties of Podophyllin Hexandrum make it a valuable asset in modern medicine, offering multiple avenues for therapeutic intervention and pharmaceutical innovation.

The Raw Material from which Podophyllin Hexandrum is Obtained

Overview of Raw Material

The primary raw material for extracting Podophyllin Hexandrum is the rhizome of the Himalayan Mayapple plant (Podophyllum hexandrum). This perennial herbaceous plant is indigenous to the Himalayan region and is characterized by its broad, umbrella-shaped leaves and small, red berries.

The rhizome of the Himalayan Mayapple plant contains a rich reservoir of bioactive compounds, including podophyllotoxin, the key component sought after in pharmaceutical and healthcare industries. The extraction of Podophyllin Hexandrum involves careful selection and processing of high-quality rhizomes to ensure optimal yield and purity of the final product.

Alternative Sources of Raw Material for Extracting Podophyllin Hexandrum

While the Himalayan Mayapple plant remains the primary source of Podophyllin Hexandrum, alternative sources for obtaining podophyllotoxin have been explored:

  • American Mayapple (Podophyllum peltatum): The American Mayapple plant, native to North America, contains podophyllotoxin in its rhizome. However, the concentration of podophyllotoxin in this species is lower compared to Podophyllum hexandrum.
  • Synthetic Production: Synthetic methods for producing podophyllotoxin have been developed, offering an alternative to plant-based extraction. However, synthetic production methods may be costlier and less environmentally sustainable compared to natural extraction.

HimPharm Manufacturing Standards

HimPharm's Role in Podophyllin Hexandrum Production

HimPharm stands as a pioneer in the production of Podophyllin Hexandrum, exemplifying excellence and innovation in pharmaceutical manufacturing. With over four decades of experience, HimPharm has established itself as a trusted leader in the industry, delivering high-quality Podophyllin Resin BP to global markets.

At HimPharm, every stage of the production process is meticulously controlled and monitored to ensure adherence to stringent quality standards. From raw material procurement to final product formulation, HimPharm maintains a relentless commitment to excellence, setting benchmarks for manufacturing practices in the pharmaceutical sector.

Upholding International Quality Standards

HimPharm’s dedication to upholding international quality standards is unwavering. The company operates in compliance with Good Manufacturing Practices (GMP) and adheres to regulations set forth by regulatory authorities worldwide. Stringent quality control measures are implemented at every stage of production to guarantee the safety, efficacy, and purity of Podophyllin Hexandrum.

HimPharm’s state-of-the-art manufacturing facilities are equipped with advanced technology and infrastructure, enabling precise control over production processes and ensuring consistency in product quality. By prioritizing quality assurance, HimPharm instills confidence in its customers and partners, reinforcing its reputation as a reliable provider of pharmaceutical-grade products.

HimPharm's Commitment to Fulfilling Your Bulk Requirements for Podophyllin Hexandrum

HimPharm recognizes the diverse needs of its customers and is committed to fulfilling bulk requirements for Podophyllin Hexandrum with utmost efficiency and reliability. Whether catering to large-scale pharmaceutical manufacturers or smaller enterprises, HimPharm leverages its manufacturing capabilities to accommodate varying demand levels and timelines.

With a focus on customer satisfaction, HimPharm offers flexible solutions tailored to meet specific requirements and preferences. The company’s responsive customer service ensures seamless communication and support throughout the procurement process, facilitating smooth transactions and fostering long-term partnerships.

Podophyllin Hexandrum Production Processes

Details of the Step-by-Step Manufacturing Process of Podophyllin Hexandrum

The manufacturing process of Podophyllin Hexandrum at HimPharm involves a series of meticulously orchestrated steps to ensure the highest quality and purity of the final product:

  1. Raw Material Selection: High-quality rhizomes of the Himalayan Mayapple plant are carefully selected for extraction, ensuring optimal potency and purity.
  2. Extraction: The selected rhizomes undergo solvent-based extraction to isolate podophyllotoxin and other bioactive compounds.
  3. Purification: The extracted material is subjected to purification processes to remove impurities and contaminants, enhancing the product’s quality and safety.
  4. Concentration: The purified extract is concentrated to increase the potency of active compounds, ensuring therapeutic efficacy.
  5. Quality Control Testing: Rigorous quality control testing is conducted throughout the manufacturing process to assess the purity, potency, and safety of Podophyllin Hexandrum.

Testing in Podophyllin Hexandrum Manufacturing

Quality control testing is an integral part of Podophyllin Hexandrum manufacturing at HimPharm. Various analytical techniques and validation protocols are employed to ensure product integrity and compliance with regulatory standards:

  • Identity Testing: Macroscopic and microscopic examination to verify the authenticity and botanical identity of raw materials.
  • Purity Analysis: Chemical analysis to assess the purity of the extracted compound and detect any impurities.
  • Potency Assay: Determination of the concentration of active compounds, particularly podophyllotoxin, to ensure therapeutic efficacy.
  • Microbiological Testing: Screening for microbial contaminants to maintain product safety and compliance.
  • Stability Testing: Evaluation of product stability under different storage conditions to determine shelf-life and maintain product integrity over time.

Navigating Production Bottlenecks in Podophyllin Hexandrum Manufacturing

In the dynamic landscape of pharmaceutical manufacturing, production bottlenecks may arise, posing challenges to efficiency and productivity. HimPharm employs proactive strategies to identify and overcome potential bottlenecks, ensuring smooth operations and timely delivery:

  • Raw Material Sourcing: Ensuring a consistent and reliable supply of high-quality raw materials to sustain manufacturing operations.
  • Process Optimization: Streamlining manufacturing processes to enhance efficiency and throughput without compromising product quality.
  • Regulatory Compliance: Adhering to stringent regulatory requirements and maintaining compliance with international quality standards.
  • Supply Chain Management: Managing logistics and distribution channels to minimize lead times and ensure timely delivery of finished products.

HimPharm’s proactive approach and commitment to excellence enable the company to navigate production bottlenecks effectively, ensuring uninterrupted supply and consistent product quality.

HimPharm’s Manufacturing Advantage

HimPharm’s manufacturing advantage lies in its unwavering commitment to excellence, innovation, and customer satisfaction. With state-of-the-art facilities, stringent quality control measures, and a dedicated team of professionals, HimPharm is poised to meet the evolving needs of the pharmaceutical industry and deliver products of unparalleled quality and efficacy.

By embracing advanced technologies, adhering to international quality standards, and fostering collaborative partnerships, HimPharm continues to drive progress and innovation in pharmaceutical manufacturing, setting new benchmarks for excellence and reliability.

Conclusion

In conclusion, Podophyllin Hexandrum, also known as Podophyllin Emodi, is a versatile botanical extract with diverse applications in the pharmaceutical and healthcare industries. From its historical use as a purgative and emetic to its modern applications in cancer treatment and dermatology, Podophyllin Hexandrum has remained a valuable asset in medicinal practices.

HimPharm, with its decades-long legacy of excellence in pharmaceutical manufacturing, stands as a beacon of quality and innovation in the production of Podophyllin Hexandrum. Through stringent quality control measures, state-of-the-art facilities, and a commitment to customer satisfaction, HimPharm continues to redefine industry standards and meet the evolving needs of its global clientele.

Leveraging HimPharm’s expertise and manufacturing capabilities, pharmaceutical companies, healthcare institutions, and research organizations can access high-quality Podophyllin Hexandrum to support their therapeutic interventions and product formulations. 

As the demand for plant-based medicines and natural remedies continues to rise, HimPharm remains dedicated to delivering premium-quality botanical extracts that uphold the highest standards of safety, efficacy, and purity.

Partner with HimPharm today and unlock the potential of Podophyllin Hexandrum for your pharmaceutical and healthcare needs. Experience the difference that quality, reliability, and innovation can make in driving your success in the competitive landscape of the healthcare industry.

Write to or Call HimPharm to Request a Quote, COA, and MSDS.

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