Home » Portfolio items » Phytochemicals » Quinine, Quinine Sulphate and Quinine Hydrochloride
Category: Phytochemical
Trade Names: Qualaquin, Quinamm, Quiphile,
Routes of Administration: Oral, Intravenous, Intramuscular
ATC Code: P01BC01
Identifiers
Chemical and Physical Data
SMILES: CC1=C(C(CCC1)(C)C)C2=CC(=CN=C2)C3=C(C(=C(C=C3)OC)OC)O
InChI: InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)16-6-8-21-18-5-4-15(23-2)11-17(16)18/h4-6,8,11-14,19,21H,3,7,9-10H2,1-2H3
Quinine stands as a natural white crystalline alkaloid renowned for its multiple properties, including antipyretic, antimalarial, analgesic, and anti-inflammatory attributes, alongside its distinct bitter taste. Originating from the bark of the cinchona tree, it holds a pivotal place in medicinal history, particularly in combating malaria.
Quinine’s discovery dates back to 1820, marking a pivotal milestone in the therapeutic landscape, as it became the first chemical compound utilized to treat an infectious disease.
With its molecular formula of C20H24N2O2, Quinine emerges as a potent blood schizonticidal agent, effectively targeting the asexual erythrocytic forms of various Plasmodium species, including P. falciparum, P. malariae, P. ovale, and P. vivax. However, it remains inactive against sporozoites or preerythrocytic forms of plasmodia.
Despite its bitter taste, Quinine serves as a vital component in tonic water, contributing to its characteristic flavor profile.
Impact of Quinine on Pharmaceutical, Drug, and Natural Products Industry
The advent of Quinine revolutionized the approach to malaria treatment, significantly impacting the pharmaceutical, drug, and natural products industries. Its efficacy in combating chloroquine-resistant strains of Plasmodium falciparum proved instrumental in addressing the escalating challenge of drug resistance.
Furthermore, Quinine’s versatility extends beyond malaria treatment, finding applications in nocturnal leg cramps and babesiosis therapy. Quinine’s historical significance transcends its medicinal prowess, shaping cultural phenomena such as the renowned gin and tonic cocktail.
Originating from British colonials in India, who ingeniously combined Quinine-infused tonic water with gin to mitigate its bitter taste, the concoction has endured as a classic beverage choice.
In essence, Quinine’s deep impact underscores its pivotal role in shaping therapeutic interventions and cultural practices, bridging the fields of science, medicine, and societal customs.
What is Quinine?
Quinine, classified as a basic amine, represents a key alkaloid derived from the bark of the cinchona tree. Its molecular structure, comprising carbon, hydrogen, nitrogen, and oxygen atoms, imbues it with distinctive pharmacological properties, rendering it indispensable in malaria therapy and beyond.
What is Quinine used in?
Quinine finds primary utilization in malaria treatment, particularly in cases resistant to chloroquine. Additionally, it serves as a therapeutic option for addressing nocturnal leg cramps and babesiosis. Furthermore, Quinine’s inclusion in tonic water underscores its historical association with combating malaria in colonial times.
What does it look like?
Quinine manifests as a white crystalline substance with a characteristic bitter taste. Its crystalline structure reflects its purity and potency, making it a valuable asset in pharmaceutical formulations.
Where does it come from – how is it obtained or processed?
Quinine is extracted from the bark of the cinchona tree, predominantly sourced from regions such as South America and Asia. The extraction process involves macerating the bark, followed by solvent extraction and purification to isolate Quinine alkaloids.
Why is it considered important?
Quinine’s significance stems from its efficacy in malaria treatment, particularly in regions plagued by drug-resistant strains. Its ability to target Plasmodium parasites underscores its indispensable role in global health initiatives aimed at eradicating malaria.
Where does it find use in?
Quinine finds widespread utilization in the pharmaceutical industry for malaria therapy, as well as in the beverage industry, imparting its characteristic bitter taste to tonic water. Moreover, its applications extend to nocturnal leg cramp alleviation and babesiosis treatment, reflecting its versatile pharmacological profile.
What is the history of Quinine?
Quinine Uses and Properties
Quinine boasts a spectrum of pharmacological properties that render it indispensable across various therapeutic domains. Its primary role lies in combating malaria, particularly in cases resistant to conventional antimalarial agents like chloroquine. As a blood schizonticidal agent, Quinine effectively targets the asexual erythrocytic forms of Plasmodium parasites, including P. falciparum, P. malariae, P. ovale, and P. vivax.
Furthermore, Quinine exhibits analgesic properties, making it a viable option for alleviating nocturnal leg cramps, a condition characterized by involuntary muscle contractions during sleep. Its anti-inflammatory attributes contribute to its efficacy in managing inflammatory conditions, albeit with caution due to its potential side effects.
Beyond its therapeutic applications, Quinine finds usage in the beverage industry, notably as a flavor component in tonic water. Its bitter taste not only enhances the sensory experience but also harks back to its historical role in combating malaria in colonial times.
List of Uses and Their Explanation
Additional Properties
Apart from its therapeutic uses, Quinine possesses several additional properties that merit attention:
In essence, Quinine’s properties and diverse applications underscore its significance in pharmaceuticals, health, and the broader spectrum of human well-being.
Quinine, a remarkable alkaloid with potent antimalarial properties, traces its origins to the bark of the Cinchona tree. This botanical marvel serves as the primary reservoir for Quinine, harboring high concentrations of the alkaloid within its bark.
The Cinchona tree, indigenous to the Andean regions of South America, is renowned for its historical significance in the treatment of malaria and its pivotal role in shaping the course of medical history.
While the Cinchona tree remains the primary source of Quinine, advancements in biotechnology and synthetic chemistry have spurred exploration into alternative avenues for Quinine production. Synthetic methodologies offer the prospect of circumventing the logistical challenges associated with sourcing natural Quinine, providing a sustainable and cost-effective alternative for meeting global demand.
Additionally, biotechnological approaches, including microbial fermentation and plant tissue culture, offer promising avenues for Quinine production. These innovative techniques leverage the inherent metabolic capabilities of microorganisms and plant cells to biosynthesize Quinine and its derivatives in controlled laboratory settings.
However, despite the allure of synthetic and biotechnological approaches, the Cinchona tree retains its status as the quintessential source of Quinine, revered for its historical legacy and botanical richness.
In summary, while alternative sources of Quinine hold promise for addressing supply chain constraints and expanding production capacities, the Cinchona tree remains irreplaceable in its role as nature’s reservoir of Quinine and a symbol of medicinal heritage.
HimPharm’s Role in Quinine Production
HimPharm is a Quinine Manufacturer and has been manufacturing Quinine for a few decades by leveraging their experience and edge manufacturing practices to deliver premium-quality Quinine derivatives including Quinine HCL & Quinine Sulfate. With a rich legacy dating back to 1979, HimPharm stands as a beacon of excellence in the pharmaceutical industry, epitomizing innovation, integrity, and unwavering commitment to quality.
At the heart of HimPharm’s Quinine production lies a relentless pursuit of excellence, characterized by stringent quality control measures and adherence to international regulatory standards. Through a harmonious blend of tradition and technology, HimPharm crafts Quinine derivatives of unparalleled purity and potency, catering to the diverse needs of global pharmaceutical markets.
Upholding International Quality Standards
HimPharm’s unwavering commitment to quality extends beyond mere compliance with regulatory mandates, embracing a culture of continuous improvement and innovation. Every stage of the manufacturing process, from raw material procurement to final product formulation, undergoes rigorous scrutiny to ensure adherence to international quality benchmarks.
Moreover, HimPharm’s state-of-the-art manufacturing facilities are equipped with advanced analytical instrumentation and quality control protocols, enabling real-time monitoring and assessment of product integrity. Through meticulous attention to detail and adherence to Good Manufacturing Practices (GMP), HimPharm ensures that its Quinine derivatives meet the highest standards of safety, efficacy, and purity.
HimPharm’s Commitment to Fulfilling Your Bulk Requirements for Quinine
As a trusted partner in pharmaceutical manufacturing, HimPharm is a Quinine manufacturer in India dedicated to meeting the diverse needs of its clientele, including bulk requirements for Quinine derivatives. Whether servicing the demands of multinational pharmaceutical conglomerates or catering to niche market segments, HimPharm offers scalable production capacities and flexible manufacturing solutions to accommodate varying order volumes.
Furthermore, HimPharm’s robust supply chain management practices and streamlined logistics ensure timely delivery of Quinine derivatives to clients worldwide. With a steadfast focus on customer satisfaction and operational excellence, HimPharm stands poised to address the evolving needs of the pharmaceutical industry, driving innovation and value creation across the supply chain.
In essence, HimPharm’s unwavering commitment to manufacturing excellence, coupled with its customer-centric approach, positions it as a preferred partner for sourcing premium-quality Quinine derivatives and driving transformative change in the global pharmaceutical landscape.
The manufacturing journey of Quinine unfolds through a meticulously orchestrated series of steps, each contributing to the synthesis and purification of this invaluable alkaloid. HimPharm’s state-of-the-art facilities and cutting-edge technologies enable the seamless execution of each manufacturing stage, ensuring the production of Quinine derivatives of uncompromising quality and purity.
Step 1: Raw Material Procurement The process commences with the meticulous selection and procurement of high-quality Cinchona bark, sourced from trusted suppliers adhering to stringent quality standards. The bark, rich in Quinine alkaloids, serves as the primary raw material for Quinine extraction.
Step 2: Extraction and Isolation The Cinchona bark undergoes extraction using solvent-based techniques, where the alkaloids are dissolved and isolated from the plant material. This process involves the careful selection of solvents and extraction conditions to optimize yield and purity.
Step 3: Purification The extracted Quinine undergoes purification to remove impurities and unwanted compounds, ensuring the final product meets pharmaceutical-grade standards. Various purification techniques, including chromatography and crystallization, are employed to achieve optimal purity and potency.
Step 4: Concentration Following purification, the Quinine extract is concentrated to enhance the potency and efficacy of the alkaloid. Concentration techniques, such as evaporation and distillation, are utilized to increase the concentration of Quinine in the final product.
Step 5: Quality Control Testing Throughout the manufacturing process, rigorous quality control testing is conducted to assess the purity, potency, and safety of the Quinine derivatives. Analytical techniques, including high-performance liquid chromatography (HPLC) and spectroscopy, are employed to ensure adherence to pharmacopeial standards and regulatory requirements.
Step 6: Packaging and Distribution Upon successful completion of quality control testing, the finalized Quinine derivatives undergo packaging and labeling procedures before distribution to pharmaceutical companies, healthcare institutions, and bulk consumers worldwide. Packaging materials are selected to ensure product integrity, stability, and compliance with regulatory guidelines.
Quality control testing serves as a cornerstone of Quinine manufacturing at HimPharm, covering a comprehensive array of analytical techniques and validation protocols to ensure product integrity and potency. Through meticulous testing and analysis, HimPharm maintains the highest standards of quality and safety across its Quinine product portfolio.
In the dynamic landscape of pharmaceutical manufacturing, production bottlenecks pose inherent challenges that require proactive management and innovative solutions. HimPharm remains vigilant in identifying and addressing potential bottlenecks, leveraging its expertise, infrastructure, and technological capabilities to streamline production processes and enhance operational efficiency.
Raw Material Sourcing: Ensuring a consistent and reliable supply of high-quality Cinchona bark, HimPharm collaborates with trusted suppliers and implements robust procurement strategies to mitigate supply chain risks and fluctuations in raw material availability.
Process Optimization: Continuously optimizing manufacturing processes to enhance efficiency, throughput, and resource utilization, HimPharm employs lean manufacturing principles and advanced process technologies to minimize waste and maximize productivity.
Regulatory Compliance: Navigating complex regulatory requirements and ensuring adherence to international quality standards, HimPharm maintains robust quality management systems and conducts regular audits and inspections to uphold compliance with regulatory guidelines.
Supply Chain Logistics: Managing logistics and distribution channels to minimize lead times and ensure timely delivery of Quinine derivatives to clients worldwide, HimPharm employs sophisticated supply chain management practices and strategic partnerships to optimize inventory levels and mitigate transportation risks.
In summary, HimPharm’s proactive approach to production bottlenecks, coupled with its commitment to operational excellence and innovation, positions it as a trusted partner in Quinine manufacturing, driving efficiency, reliability, and value creation across the pharmaceutical supply chain.
How HimPharm Helps Overcome Challenges and Ensures Quality
HimPharm’s manufacturing advantage lies in its unwavering commitment to excellence, innovation, and customer satisfaction. With decades of experience and a legacy of pharmaceutical manufacturing, HimPharm is poised to meet the evolving needs of the global market, offering a comprehensive suite of services and solutions tailored to the pharmaceutical, healthcare, and nutraceutical industries.
In conclusion, HimPharm’s manufacturing advantage is rooted in its unwavering dedication to quality, innovation, and customer satisfaction. With a focus on expertise, state-of-the-art facilities, quality assurance, scalability, and continuous improvement, HimPharm stands as a trusted partner in Quinine manufacturing, delivering value, reliability, and excellence to clients worldwide.
In summary, the journey through the world of Quinine and its derivatives unveils a fascinating tapestry of science, history, and innovation. From its humble origins in the bark of the Cinchona tree to its pivotal role in modern medicine, Quinine stands as a testament to the power of nature and human ingenuity.
Recap of Key Insights
Throughout this exploration, we have looked into the diverse nature of Quinine, uncovering its many pharmacological properties and therapeutic applications. From its antimalarial efficacy to its use as a bitter flavoring agent in tonic water, Quinine continues to shape the landscape of healthcare and wellness.
We have traced the historical trajectory of Quinine, from its discovery by Jesuit missionaries in the New World to its widespread adoption as a frontline treatment for malaria. Along the way, we have encountered tales of exploration, scientific inquiry, and medical breakthroughs, highlighting the huge impact of Quinine on human history and society.
Leveraging HimPharm’s Commitment to Quality
As we navigate the complex terrain of pharmaceutical manufacturing, HimPharm emerges as a beacon of excellence and reliability. With its decades-long legacy of innovation and expertise, HimPharm remains steadfast in its commitment to delivering top-quality Quinine derivatives to the global market.
By harnessing the latest advancements in technology, adhering to stringent quality standards, and prioritizing customer satisfaction, HimPharm sets a new standard for excellence in Quinine production. Whether clients seek bulk quantities of Quinine Sulphate or Quinine Hydrochloride, HimPharm stands ready to meet their needs with efficiency, precision, and integrity.
Empowering Your Pharmaceutical Endeavors
As you embark on your pharmaceutical journey, HimPharm stands as your trusted partner and ally. With its state-of-the-art facilities, unwavering commitment to quality, and dedication to innovation, HimPharm offers a gateway to success in the dynamic world of Quinine manufacturing.
Write to or Call HimPharm to Request a Quote, COA, and MSDS.
for
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.
©
2024
HimPharm.com. All Rights Reserved.