Santonin

Santonin IP

Written by

Reviewed by

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Gaurav Sood

Partner - HimPharm

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Dr B M Sood

Chairman - HimPharm

Santonin Manufactured by HimPharm

Category: Phytochemical
Trade Names: Not Applicable, generally sold as Santonin
Routes of Administration: Oral ingestion
ATC Code: Not applicable

Identifiers

  • CAS Number: 481-06-1
  • PubChem CID: 442794
  • ChemSpider ID: 391539
  • IUPAC Name: (1R,4S,5S,6S,7R,8S,10R)-4,7,8-trihydroxy-6,6,10-trimethyl-5-oxo-3-oxa-9-azatricyclo[6.3.1.0²,⁶]dodecan-2-one
  • UNII: 4A5T80D3EB
  • KEGG ID: C06523
  • ChEBI ID: 28171
  • ChEMBL ID: CHEMBL1253322
  • CompTox Dashboard (EPA): DTXSID8022412
  • ECHA InfoCard: 100.007.512

Chemical and Physical Data

  • Molecular Formula C15H18O5
  • Molar Mass 278.30 g/mol

SMILES: CC1(C2C(C(=O)C3(C4(CC(C(O4)(C)C)OC3=O)C)OC2C(O1)C)O

InChI: InChI=1S/C15H18O5/c1-7-3-8-12(16)13(17)15(18-14(8)20-7)11(19)6-10(18)9(7)5-2-4-21-15/h3,9-11,13,16-17,19H,2,4-6H2,1H3/t7-,9+,10-,11-,13-,15+/m0/s1

Introduction

Santonin

Santonin, an alkaloid or phytochemical, has been recognized for its anthelmintic properties. This organic compound, with the molecular formula C27H30O16, is utilized in expelling parasitic worms, notably Ascaris lumbricoides, from the human body. Historically, Santonin was a crucial component in anthelmintic treatments, offering a means to combat roundworm infestations and threadworm parasitosis effectively. While its usage has evolved over time, Santonin remains a significant therapeutic agent in the pharmaceutical industry.

Santonin

Impact of Santonin on Pharmaceutical Industry

The emergence of Santonin revolutionized the approach to treating helminth infections, particularly Ascaris lumbricoides infestations. Its efficacy in paralyzing parasitic worms, coupled with the administration of purgatives, facilitated the expulsion of these pathogens from the host’s body. 

Such advancements not only enhanced patient care but also propelled the pharmaceutical industry towards more effective anthelmintic solutions. The introduction of Santonin marked a pivotal moment in the history of parasitic infection management, paving the way for further research and development in anthelmintic therapies.

Understanding Santonin

What is Santonin?

Santonin is a naturally occurring compound, characterized by colorless flat prisms that exhibit slight yellowing upon exposure to light. Soluble in alcohol, chloroform, and boiling water, Santonin possesses unique pharmacological properties that make it a potent anthelmintic agent.

Santonin’s Uses

Santonin finds its primary application in the treatment of infestations caused by Ascaris lumbricoides, commonly known as roundworms. Additionally, Santonin is instrumental in addressing various ascarid parasitoses, including threadworm parasitosis, reflecting its broad spectrum of anthelmintic activity.

Physical Characteristics of Santonin

The physical appearance of Santonin is defined by its colorless flat prisms, which undergo a subtle yellowing process upon exposure to light. This distinctive feature, alongside its solubility in alcohol, chloroform, and boiling water, underscores its unique chemical composition and pharmaceutical utility.

Source and Extraction of Santonin

Santonin is sourced from select botanical species known to contain high concentrations of the compound. The extraction process involves isolating Santonin from its natural source through meticulous extraction and purification techniques, ensuring the integrity and potency of the final product.

Significance of Santonin

The significance of Santonin lies in its ability to effectively paralyze parasitic worms, facilitating their expulsion from the host’s body. This mechanism of action, coupled with its compatibility with purgatives, underscores its role as a cornerstone in anthelmintic therapy.

Industrial Applications of Santonin

Beyond its therapeutic uses, Santonin holds promise in various industrial applications, including pharmaceutical formulations and research endeavors. Its unique pharmacological properties render it a valuable asset in the development of novel anthelmintic therapies and drug formulations.

History of Santonin

Santonin’s discovery and subsequent utilization in anthelmintic treatments mark significant milestones in the history of parasitic infection management. From its initial recognition to its widespread adoption in medical practice, Santonin has played a pivotal role in advancing anthelmintic therapies.

Exploring Santonin and its Pharmaceutical Use

Santonin Uses and Properties

Santonin’s pharmacological properties is based on its ability to induce paralysis in parasitic worms, facilitating their expulsion from the host’s gastrointestinal tract. This mechanism of action, attributed to its interaction with the nervous system of the parasites, underscores its efficacy in treating helminth infections.

Santonin’s Therapeutic Uses

Santonin’s therapeutic utility extends beyond its anthelmintic properties, showcasing its role in addressing various gastrointestinal disorders and related complications. Its ability to alleviate symptoms associated with parasitic infestations further underscores its therapeutic significance in medical practice.

Additional Properties of Santonin

In addition to its anthelmintic and therapeutic properties, Santonin exhibits notable chemical characteristics that contribute to its pharmacological activity. Its solubility in alcohol, chloroform, and boiling water, coupled with its stable crystalline structure, enhances its suitability for pharmaceutical formulations and research applications.

The Raw Material for Santonin: Natural Sources

Raw Material Overview

Santonin is derived from select botanical sources including Artemisia maritima, amongst others known to contain high concentrations of the compound. These natural sources serve as the primary reservoirs for Santonin extraction, providing the raw material necessary for pharmaceutical production and research endeavors.

Alternative Sources for Santonin Extraction

While traditional botanical sources remain the primary reservoirs for Santonin extraction, alternative sources have garnered attention for their potential in augmenting production capabilities. The exploration of alternative sources underscores the pharmaceutical industry’s commitment to sustainability and innovation in Santonin production.

HimPharm Manufacturing Standards

HimPharm’s Role in Santonin Production

HimPharm, a leading pharmaceutical manufacturer, plays a pivotal role in Santonin production, leveraging its extensive experience and manufacturing capabilities to meet global demand. With a legacy spanning decades, HimPharm remains committed to upholding the highest standards of quality and efficiency in Santonin manufacturing.

Upholding International Quality Standards

HimPharm’s adherence to international quality standards underscores its commitment to excellence in Santonin production. Through stringent quality control measures and state-of-the-art manufacturing facilities, HimPharm ensures the integrity and purity of its Santonin products, meeting the diverse needs of its global clientele.

Fulfilling Bulk Requirements for Santonin

HimPharm’s production capabilities enable it to fulfill bulk requirements for Santonin, catering to the evolving needs of the pharmaceutical industry. With a robust supply chain and streamlined production processes, HimPharm remains at the forefront of Santonin production, supporting the development and distribution of life-saving medications worldwide.

Santonin Production Processes

Manufacturing Process of Santonin

The manufacturing process of Santonin entails a series of meticulously orchestrated steps aimed at ensuring purity, potency, and safety. From raw material procurement to final formulation, each stage is characterized by stringent quality control measures and adherence to Good Manufacturing Practices (GMP).

Step 1: Raw Material Procurement The process commences with the sourcing of high-quality botanical materials known to contain significant concentrations of Santonin. HimPharm’s extensive network of suppliers ensures the availability of premium raw materials essential for Santonin extraction.

Step 2: Extraction and Isolation Selected botanical materials undergo extraction using advanced techniques to isolate Santonin from other plant constituents. This extraction process, conducted under controlled conditions, ensures optimal yield and purity of the Santonin extract.

Step 3: Purification and Refinement The extracted Santonin undergoes purification and refinement processes to remove impurities and contaminants, resulting in a highly pure and potent compound suitable for pharmaceutical use. Through chromatographic techniques and filtration methods, HimPharm achieves the desired level of purity in its Santonin products.

Step 4: QC and Packaging Once purified, Santonin undergoes rigorous quality control testing before packaging to ensure product integrity and safety.

Quality Control Testing in Santonin Manufacturing

Quality control testing serves as a cornerstone of Santonin manufacturing at HimPharm, ensuring compliance with regulatory standards and product specifications. Through a combination of analytical techniques and validation protocols, each batch of Santonin undergoes comprehensive testing for purity, potency, and safety.

  • Identity Testing: Santonin undergoes identity testing to verify its authenticity and botanical origin, ensuring compliance with regulatory requirements and industry standards.
  • Purity Analysis: The purity of Santonin is assessed through chemical analysis to determine the absence of impurities and contaminants, ensuring product safety and efficacy.
  • Potency Assay: Santonin’s potency is evaluated to determine its concentration of active ingredients, ensuring consistency and efficacy across batches.
  • Microbiological Testing: Santonin undergoes microbiological testing to detect and eliminate microbial contaminants, safeguarding product quality and patient safety.
  • Stability Testing: Santonin undergoes stability testing to assess its shelf-life and performance under various storage conditions, ensuring product integrity and efficacy over time.

Addressing Production Challenges

In the dynamic landscape of pharmaceutical manufacturing, production challenges can arise, necessitating proactive measures and strategic interventions. HimPharm remains vigilant in identifying and addressing potential bottlenecks to ensure uninterrupted Santonin production and timely delivery to customers worldwide.

  • Raw Material Sourcing: HimPharm maintains strategic partnerships with suppliers to ensure a consistent and reliable supply of high-quality botanical materials essential for Santonin production.
  • Process Optimization: HimPharm continually optimizes its manufacturing processes to enhance efficiency and productivity while maintaining the highest standards of quality and safety.
  • Regulatory Compliance: HimPharm remains committed to regulatory compliance, adhering to international quality standards and regulatory requirements governing Santonin manufacturing.
  • Supply Chain Logistics: HimPharm manages its supply chain logistics meticulously to minimize lead times and ensure timely delivery of Santonin products to customers across the globe.

Through proactive management strategies and continuous improvement initiatives, HimPharm navigates production challenges effectively, ensuring seamless Santonin production and supply to meet global demand.

Global Impact and Market Presence

Global Distribution and Market Reach

HimPharm’s commitment to excellence in Santonin production has propelled its products to markets worldwide, establishing a robust global presence. Through strategic alliances, distribution networks, and regulatory approvals, HimPharm has expanded its market reach, catering to diverse pharmaceutical industries and healthcare sectors across continents.

Market Dynamics and Emerging Trends

The global market for Santonin and phytochemicals continues to evolve, driven by emerging healthcare trends, technological advancements, and shifting consumer preferences. As a leading player in the industry, HimPharm remains attuned to market dynamics and anticipates emerging trends to capitalize on new opportunities and meet evolving customer needs.

Competitive Landscape and Market Positioning

In a competitive marketplace, HimPharm distinguishes itself through a combination of product excellence, manufacturing expertise, and customer-centric approach. By offering high-quality Santonin products backed by reliable supply chains and responsive customer service, HimPharm maintains a competitive edge and solidifies its position as a preferred supplier in the global pharmaceutical market.

Conclusion

In conclusion, HimPharm’s legacy of excellence in Santonin production reflects a steadfast commitment to quality, innovation, and customer satisfaction. With a rich history spanning over four decades, HimPharm has emerged as a trusted leader in the pharmaceutical industry, renowned for its cutting-edge manufacturing capabilities, stringent quality standards, and unwavering dedication to healthcare excellence.

As the demand for natural remedies and phytochemical-based therapies continues to rise, HimPharm remains poised to meet the evolving needs of the global healthcare market, driving innovation, advancing scientific research, and enhancing patient care worldwide. With a clear vision for the future and a steadfast commitment to its core values, HimPharm stands ready to shape the future of healthcare through its continued pursuit of excellence in Santonin production and beyond.

Through collaboration, innovation, and a relentless pursuit of excellence, HimPharm remains dedicated to advancing human health and well-being, one Santonin molecule at a time.

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These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease.

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